The Effect of Long Term Moderate Exercise on Depressive / Anxiety-Like Behavior in Rats with Acute REM Sleep Deprivation

Authors

  • Leyla Şahin Mersin Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Çiftlikköy Kampüsü, 34333 Yenişehir/Mersin

DOI:

https://doi.org/10.24925/turjaf.v6i11.1640-1646.2161

Keywords:

Sleep deprivation, Exercise, Anxiety, Rat, Behaviour

Abstract

Sleep is a physiological process that influenced by internal and external factors and brain is as active as waking in certain periods. REM sleep is demonstrated in the literature that provides psychological relaxation due to more frequent occurrence of psychiatric disorders in sleep deprivation and causes depression / anxiety-like situations. There are studies in the literature indicate that physical exercise may be useful on depressive / anxiety. However, the duration and physical severity of the physical exercise and sleep deprivation affects the results. For this reason, we investigated the effect of long-term exercise on depression / anxiety behavior on acute REM sleep deprived rats. Rats were divided into control (C), exercise (E), REM sleep deprivation (SD) and exercise + REM sleep deprivation (E + SD) (n = 7). For developing REM sleep deprivation, rats were kept in a sleep deprivation tank during a 48-hour period. Exercise was performed with treadmill for 15, 30, 45 and 60 minutes for 4 weeks. Depressive / anxiety behaviors were assessed with open field and elevated plus maze tests. It has been shown that the sleep deprivation group takes less distance in the open field test. It was observed that in the elevated plus maze test, the rats in the sleep deprivation group spent less time on the open-arm compared to the other groups, and the number of entries and exits in this group also decreased. Behavioral test findings show that depressive / anxiety-like effects of sleep deprivation are reduced by moderate treadmill exercise.

Published

29.10.2018

How to Cite

Şahin, L. (2018). The Effect of Long Term Moderate Exercise on Depressive / Anxiety-Like Behavior in Rats with Acute REM Sleep Deprivation. Turkish Journal of Agriculture - Food Science and Technology, 6(11), 1640–1646. https://doi.org/10.24925/turjaf.v6i11.1640-1646.2161

Issue

Section

Research Paper