Phytochemical Screening, Antioxidant, Antiulcer, Anti-Inflammatory and Analgesic Activity of the Aqueous Extract of Angelica archangelica

Authors

  • Walid Mamache Department of Biochemistry, Faculty of Nature and Life Sciences, University of Ferhat Abbas Setif -1-, Setif, Algeria. Laboratory of Applied Phytotherapy to Chronic Diseases, University of Ferhat Abbas Setif -1-, Setif, Algeria http://orcid.org/0000-0002-8567-5634
  • Abderrahim BENSLAMA Department of Biochemistry and Microbiology, University of M‘sila, Faculty of Sciences, M‘sila http://orcid.org/0000-0002-8626-6269
  • Fatima Benchikh Department of Biology and animal physiology, Faculty of Nature and Life Sciences, University of Ferhat Abbas Setif -1-, Setif, Algeria. Laboratory of Applied Phytotherapy to Chronic Diseases, University of Ferhat Abbas Setif -1-, Setif, Algeria http://orcid.org/0000-0002-8567-5634
  • Hassiba Benabdellah Department of Biology and animal physiology, Faculty of Nature and Life Sciences, University of Ferhat Abbas Setif -1-, Setif, Algeria. Laboratory of Applied Phytotherapy to Chronic Diseases, University of Ferhat Abbas Setif -1-, Setif, Algeria http://orcid.org/0000-0001-8046-1066
  • Sabira Lassas Department of Biology and animal physiology, Faculty of Nature and Life Sciences, University of Ferhat Abbas Setif -1-, Setif, Algeria. http://orcid.org/0000-0002-2089-8618
  • Hind Amira Department of Biology and animal physiology, Faculty of Nature and Life Sciences, University of Ferhat Abbas Setif -1-, Setif, Algeria. http://orcid.org/0000-0003-3368-5256
  • Smain Amira Department of Biology and animal physiology, Faculty of Nature and Life Sciences, University of Ferhat Abbas Setif -1-, Setif, Algeria. Laboratory of Applied Phytotherapy to Chronic Diseases, University of Ferhat Abbas Setif -1-, Setif, Algeria http://orcid.org/0000-0003-4457-3591

DOI:

https://doi.org/10.24925/turjaf.v10i2.334-340.5023

Keywords:

Angelica archangelica, Phytchemical, Antioxidant activity, Anti-flammatory, Analgesic effect, Anti-ulcer activity

Abstract

The objective of this study is to evaluate the antioxidant, antiulcer, anti-inflammatory and analgesic activity of the aqueous extract of Angelica archangelica L., a medicinal plant of the traditional pharmacopoeia of Algeria. The aqueous extract showed a large amount of total polyphenols, tannins, chlorophyll a, b, carotenoids and a small amount of flavonoids with values of 80.16±14.3 mg EAG/g of extract, 3.12±2.01 mg EQ/g of extract, 226.10±4.50 mg EAT/g of extract, 6.10±50.62, 12.00±31.53 and 1.78±0.40 μg/mL respectively. In addition, the aqueous extract of A. archangelica showed a high ability to trap DPPH radical in with IC50 at 16.9±2.03μg/mL. However, the aqueous extract has a great protective effect against β-carotene degradation at 91.98±0.64% after 24 hours and significant ferrous ion chelation activity at46.2 ±1.53µg/mL. Furthermore, the anti-inflammatory activity was studied according to the protein denaturation inhibition method and, according to the results obtained, the extract of A. archangelica at concentrations of 250, 500 μg/mL and 1 mg/mL have ahigh antiinflammatory activity whose inhibition percentages are 78.85±5.31%, 86.65±2.70% and 89.89±0.58% respectively. The analgesic effect of the aqueous extract of A. archangelica, showed that the concentration 400 mg/mL has a greet abdominal cramps inhibitory effect in comparison with the concentration 200 mg/mL with a percentage of 98.28%. The antiulcer effect of the aqueous extract of A. archangelica was evaluated by the 70% ethanol-induced ulcer test. The results obtained reveal that the aqueous extract 200 and 400 mg/mL exerted a considerable effect of protecting the stomach at 86.55±3.51% and 82.82±2.18% respectively.

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Published

28.02.2022

How to Cite

Mamache, W., BENSLAMA, A., Benchikh, F., Benabdellah, H., Lassas, S., Amira, H., & Amira, S. (2022). Phytochemical Screening, Antioxidant, Antiulcer, Anti-Inflammatory and Analgesic Activity of the Aqueous Extract of Angelica archangelica. Turkish Journal of Agriculture - Food Science and Technology, 10(2), 334–340. https://doi.org/10.24925/turjaf.v10i2.334-340.5023

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Research Paper

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