Holy Basil (Ocimum sanctum): An Unexploited Resource of Nepal

Authors

DOI:

https://doi.org/10.24925/turjaf.v13i9.2866-2875.7806

Keywords:

holy basil, commercial, antibacterial, antioxidant, anti-inflammatory, pharmacological

Abstract

Holy basil, known as Tulasi in Nepali is a medicinal herb with significant potential in Nepal. Despite its significance in culture and tradition, its scientific and commercial potential is yet underexplored. This review article explores holy basil’s pharmacological characteristics emphasizing its adaptogenic, anti-bacterial and anti-inflammatory qualities. The medicinal uses of basil are attributed to its bioactive compounds including ursolic acid, rosmarinic acid and eugenol.  This review article highlights the necessity of systematic cultivation, sustainable harvesting and advanced extraction technique in order to optimize the yield and quality of these bioactive substances. It also explores holy basil’s potential in the cosmetic, pharmaceutical and nutraceutical sectors and advocates for further research and development to utilize its full potential. Basil’s commercial and industrial potential in Nepal is also glorified in this review article along with challenges in commercialization also providing future recommendations.

References

Abdelhameed, R. F., Eltamany, E. E., Hal, D. M., Ibrahim, A. K., AboulMagd, A. M., Al-Warhi, T., ... & Abdelmohsen, U. R. (2020). New cytotoxic cerebrosides from the red sea cucumber Holothuria spinifera supported by in-silico studies. Marine drugs, 18(8), 405.

Ahmad, M. Z., Ali, M., & Mir, S. R. (2012). Anti-diabetic activity of Ocimum sanctum L. roots and isolation of new phytoconstituents using two-dimensional nuclear magnetic resonance spectroscopy. J Pharmacogn Phytother, 4, 75-85.

Ali, A., & Ali, M. (2012). New fatty acid derivatives from Ocimum sanctum L. leaves. Indian Drugs, 49(11), 13-18.

Ali, H., & Dixit, S. (2012). In vitro antimicrobial activity of flavanoids of Ocimum sanctum with synergistic effect of their combined form. Asian Pacific Journal of Tropical Disease, 2, S396-S398.

Al-Niaimi, F., & Chiang, N. Y. Z. (2017). Topical vitamin C and the skin: mechanisms of action and clinical applications. The Journal of clinical and aesthetic dermatology, 10(7), 14.

Anand, A., Khurana, R., Wahal, N., Mahajan, S., Mehta, M., Satija, S., ... & Khurana, N. (2019). Vanillin: A comprehensive review of pharmacological activities. Plant Arch, 19(2), 1000-1004.

Angers, P., Morales, M. R., & Simon, J. E. (1996). Fatty acid variation in seed oil among Ocimum species. Journal of the American Oil Chemists’ Society, 73, 393-395.

Azubuike-Osu, S. O., Ohanenye, I. C., Jacob, C., Ejike, C. E., & Udenigwe, C. C. (2021). Beneficial role of vitexin and isovitexin flavonoids in the vascular endothelium and cardiovascular system. Current Nutraceuticals, 2(2), 127-134.

Bakrim, S., Benkhaira, N., Bourais, I., Benali, T., Lee, L. H., El Omari, N., ... & Bouyahya, A. (2022). Health benefits and pharmacological properties of stigmasterol. Antioxidants, 11(10), 1912.

Baliga, M. S., Jimmy, R., Thilakchand, K. R., Sunitha, V., Bhat, N. R., Saldanha, E., ... & Palatty, P. L. (2013). Ocimum sanctum L (Holy Basil or Tulsi) and its phytochemicals in the prevention and treatment of cancer. Nutrition and cancer, 65(sup1), 26-35.

Bano, N., Ahmed, A., Tanveer, M., Khan, G. M., & Ansari, M. T. (2017). Pharmacological evaluation of Ocimum sanctum. J Bioequiv Availab, 9(3), 387-92.

Bhamra, S. K., Heinrich, M., Johnson, M. R., Howard, C., & Slater, A. (2022). The cultural and commercial value of Tulsi (Ocimum tenuiflorum L.): Multidisciplinary approaches focusing on species authentication. Plants, 11(22), 3160.

Bhasin, M. (2012). Ocimum-Taxonomy, medicinal potentialities and economic value of essential oil. Journal of Biosphere, 1, 48-50.

Bhattacharyya, D., Sur, T. K., & Jana, U. (2021). Holy Basil (Ocimum sanctum Linn.) and ItsEfficacy in Various Health Conditions: An Overview. Pharmacognosy Journal, 13(2),365-374. doi: 10.5530/pj.2021.13.47

Bhattarai, N. K. (1991). Folk herbal medicines of Makawanpur district, Nepal. International journal of pharmacognosy, 29(4), 284-295.

Bisignano, G., Laganà, M. G., Trombetta, D., Arena, S., Nostro, A., Uccella, N., ... & Saija, A. (2001). In vitro antibacterial activity of some aliphatic aldehydes from Olea europaea L. FEMS microbiology letters, 198(1), 9-13. https://doi.org/10.1111/j.1574-6968.2001.tb10611.x

Biswas, N. P., & Biswas, A. K. (2005). Evaluation of some leaf dusts as grain protectant against rice weevil Sitophilus oryzae (Linn.).

Carr, M., & Hartl, M. (2008). Gender and non-timber forest products: Promoting food security and economic empowerment. IFAD, UK.

Chandana, M., & Vidya, G. GRISAAS–An Edited Book (Volume-3).

Chatterjee, G. (2001). Sacred Hindu Symbols. Abhinav Publications.

Chen, L., Wu, X., Shen, T., Wang, X., Wang, S., Wang, J., & Ren, D. (2019). Protective effects of ethyl gallate on H 2 O 2-induced mitochondrial dysfunction in PC12 cells. Metabolic brain disease, 34, 545-555.

Cho, J. Y., Moon, J. H., Seong, K. Y., & Park, K. H. (1998). Antimicrobial activity of 4-hydroxybenzoic acid and trans 4-hydroxycinnamic acid isolated and identified from rice hull. Bioscience, biotechnology, and biochemistry, 62(11), 2273-2276.

Cohen, M. M. (2014). Tulsi-Ocimum sanctum: A herb for all reasons. Journal of Ayurveda and integrative medicine, 5(4), 251.

Darrah, H. (1980). The Cultivated Basils. h omas Buckeye Printing Co. Independence, MI.

Działo, M., Mierziak, J., Korzun, U., Preisner, M., Szopa, J., & Kulma, A. (2016). The potential of plant phenolics in prevention and therapy of skin disorders. International journal of molecular sciences, 17(2), 160.

Farag, M. A., & Gad, M. Z. (2022). Omega-9 fatty acids: Potential roles in inflammation and cancer management. Journal of Genetic Engineering and Biotechnology, 20(1), 48.

Gingade, S., Varghese, T.S., Manivel, P. (2014). Cultivation of Ocimum. ICAR-Directorate of Medicinal and Aromatic Plants Research. Extension Bulletin.

González, M. A. (2015). Aromatic abietane diterpenoids: Their biological activity and synthesis. Natural Product Reports, 32(5), 684-704. https://doi.org/10.1039/C4NP00110A

Gülçin, İ. (2011). Antioxidant activity of eugenol: A structure–activity relationship study. Journal of medicinal food, 14(9), 975-985.

Gupta, P., Yadav, D. K., Siripurapu, K. B., Palit, G., & Maurya, R. (2007). Constituents of Ocimum sanctum with antistress activity. Journal of natural products, 70(9), 1410-1416.

Gupta, S. K., Prakash, J., & Srivastava, S. (2002). Validation of traditional claim of Tulsi, Ocimum sanctum Linn. as a medicinal plant.

Gurung, K. and Pyakurel, D. (2017). Identification Manual of Commercial Medicinal and Aromatic Plants of Nepal. Nepal Herbs and Herbal Products Association (NEHHPA). Teku, Kathmandu, Nepal.

Hernández-Valle, E., Herrera-Ruiz, M., Rosas Salgado, G., Zamilpa, A., Arenas Ocampo, M. L., Jiménez Aparicio, A., ... & Jiménez-Ferrer, E. (2014). Anti-inflammatory effect of 3-O-[(6'-O-palmitoyl)-β-D-glucopyranosyl sitosterol] from Agave angustifolia on ear edema in mice. Molecules, 19(10), 15624-15637.https://doi.org/10.3390/molecules191015624

Ibrahim, M. J., Nangia, A., Das, S., Verma, T., Rajeswari, V. D., Venkatraman, G., & Gnanasambandan, R. (2024). Exploring Holy Basil’s Bioactive Compounds for T2DM Treatment: Docking and Molecular Dynamics Simulations with Human Omentin-1. Cell Biochemistry and Biophysics, 1-18. 10.1007/s12013-024-01511-6

Jamshidi, N., & Cohen, M. M. (2017). The clinical efficacy and safety of Tulsi in humans: a systematic review of the literature. Evidence‐Based Complementary and Alternative Medicine, 2017(1), 9217567.

Jett, J. W. (2007). That Devilish Parsley West Virginia University Extension Service. Last retrieved April, 26, 2007.

Jiang, S., Wang, M., Jiang, Z., Zafar, S., Xie, Q., Yang, Y., ... & Wang, W. (2021). Chemistry and pharmacological activity of sesquiterpenoids from the Chrysanthemum genus. Molecules, 26(10), 3038 . https://doi.org/10.3390/molecules26103038

Jige, S. B. (2024). Ethnobotanical, Therapeutic, and Pharmacological Applications of Bakuchi (Psoralea corylifolia L.) Plant. In Therapeutic and Pharmacological Applications of Ethnobotany (pp. 23-37). IGI Global.

Joshi, S., & Karna, A. K. (2013). Analysis of phytoconstiuents and cytotoxic activities of different parts of Ocimum sanctum. Int. J. Appl. Sci. Biotechnol, 1(3), 137-144.

Jothie Richard, E., Illuri, R., Bethapudi, B., Anandhakumar, S., Bhaskar, A., Chinampudur Velusami, C., ... & Agarwal, A. (2016). Anti‐stress Activity of Ocimum sanctum: Possible Effects on Hypothalamic–Pituitary–Adrenal Axis. Phytotherapy Research, 30(5), 805-814

Kang, C. W., Han, Y. E., Kim, J., Oh, J. H., Cho, Y. H., & Lee, E. J. (2017). 4-Hydroxybenzaldehyde accelerates acute wound healing through activation of focal adhesion signalling in keratinocytes. Scientific reports, 7(1), 14192.

Kayastha, B. L. (2014). Queen of herbs tulsi (Ocimum sanctum) removes impurities from water and plays disinfectant role. Journal of Medicinal Plants Studies, 2(2), 01-08.

Kelm, M. A., & Nair, M. G. (1998). Mosquitocidal compounds and a triglyceride, 1, 3-dilinoleneoyl-2-palmitin, from Ocimum sanctum. Journal of agricultural and food chemistry, 46(8), 3092-3094.

Kelm, M. A., Nair, M. G., Strasburg, G. M., & DeWitt, D. L. (2000). Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn. Phytomedicine, 7(1), 7-13.

Khan, A. K., Rashid, R., Fatima, N., Mahmood, S., Mir, S., Khan, S., ... & Murtaza, G. (2015). Pharmacological activities of protocatechuic acid. Acta Pol. Pharm, 72(4), 643-650.

Khan, Z., Nath, N., Rauf, A., Emran, T. B., Mitra, S., Islam, F., ... & Thiruvengadam, M. (2022). Multifunctional roles and pharmacological potential of β-sitosterol: Emerging evidence toward clinical applications. Chemico-Biological Interactions, 365, 110117.

Khosla, M. K. (1995). Sacred tulsi (Ocimum sanctum L.) in traditional medicine and pharmacology. Ancient science of life, 15(1), 53-61.

Kim, J. Y., Pham, D. D., & Koh, B. H. (2011a). Comparison of Sasang constitutional medicine, traditional chinese medicine and Ayurveda. Evidence‐Based Complementary and Alternative Medicine, 2011(1), 239659.

Kim, M. C., Kim, S. J., Kim, D. S., Jeon, Y. D., Park, S. J., Lee, H. S., ... & Hong, S. H. (2011b). Vanillic acid inhibits inflammatory mediators by suppressing NF-κB in lipopolysaccharide-stimulated mouse peritoneal macrophages. Immunopharmacology and immunotoxicology, 33(3), 525-532.https://doi.org/10.3109/08923973.2010.547500

Krishnaswamy, K. (2008). Traditional Indian spices and their health significance. Asia Pacific journal of clinical nutrition, 17(S1), 265-268.

Kuljarusnont, S., Iwakami, S., Iwashina, T., & Tungmunnithum, D. (2024). Flavonoids and other phenolic compounds for physiological roles, plant species delimitation, and medical benefits: A promising view. Molecules, 29(22), 5351.

Kumar, N., & Goel, N. (2019). Phenolic acids: Natural versatile molecules with promising therapeutic applications. Biotechnology reports, 24, e00370. https://doi.org/10.1016/j.btre.2019.e00370

Kumar, S., & Pandey, A. K. (2013). Chemistry and biological activities of flavonoids: an overview. The scientific world journal, 2013(1), 162750.

Küpeli, E., Aslan, M., Gürbüz, İ. & Yesilada, E. (2004). Evaluation of in vivo Biological Activity Profile of Isoorientin. Zeitschrift für Naturforschung C, 59(11-12), 787-790. https://doi.org/10.1515/znc-2004-11-1204

Li, C. X., Li, J. C., Lai, J., & Liu, Y. (2022). The pharmacological and pharmacokinetic properties of esculin: A comprehensive review. Phytotherapy Research, 36(6), 2434-2448.

Liang, H., Huang, Q., Zou, L., Wei, P., Lu, J., & Zhang, Y. (2023). Methyl gallate: Review of pharmacological activity. Pharmacological Research, 106849.

Lopresti, A. L., Smith, S. J., Metse, A. P., & Drummond, P. D. (2022). A randomized, double-blind, placebo-controlled trial investigating the effects of an Ocimum tenuiflorum (Holy Basil) extract (HolixerTM) on stress, mood, and sleep in adults experiencing stress. Frontiers in Nutrition, 9, 965130.

Luitel, K. (2009, Sept 24). Eastern farmers take to Tulsi farming. The Himalayan Times. https://thehimalayantimes.com/nepal/eastern-farmers-take-to-tulsi-farming/

Manuja, R., Sachdeva, S., Jain, A., & Chaudhary, J. (2013). A comprehensive review on biological activities of p-hydroxy benzoic acid and its derivatives. Int. J. Pharm. Sci. Rev. Res, 22(2), 109-115.

Masyita, A., Sari, R. M., Astuti, A. D., Yasir, B., Rumata, N. R., Emran, T. B., ... & Simal-Gandara, J. (2022). Terpenes and terpenoids as main bioactive compounds of essential oils, their roles in human health and potential application as natural food preservatives. Food chemistry: X, 13, 100217.

Meyers, M. (2003). Basil: an herb society of America guide. The Herb Society of America: Kirtland, OH, USA, 6-7.

Mondal, S., Mirdha, B. R., & Mahapatra, S. C. (2009). The science behind sacredness of Tulsi (Ocimum sanctum Linn.). Indian J Physiol Pharmacol, 53(4), 291-306.

Nadkarni, K.M., 1976. Indian Materia Medica. Popular Prakashan, Bombay, pp. 861.

Nakano, K., Sasaki, S., & Kataoka, T. (2022). Bioactive evaluation of ursane-type pentacyclic triterpenoids: β-boswellic acid interferes with the glycosylation and transport of intercellular adhesion molecule-1 in human lung adenocarcinoma A549 cells. Molecules, 27(10), 3073.https://doi.org/10.3390/molecules27103073

Nazir, S., Chaudhary, W. A., Mobashar, A., Anjum, I., Hameed, S., & Azhar, S. (2023). Campesterol: a natural phytochemical with anti inflammatory properties as potential therapeutic agent for rheumatoid arthritis: a systematic review: campesterol: A natural phytochemical. Pakistan Journal of Health Sciences.

Nepal Desk. (n.d.). Holy Basil (Tulasi): The Queen of Herbs. Nepal Desk. Retrieved February 5, 2025, from https://nepaldesk.com/herbal/holy-basil

Nesterkina, M., & Kravchenko, I. (2017). Synthesis and pharmacological properties of novel esters based on monoterpenoids and glycine. Pharmaceuticals, 10(2), 47. https://doi.org/10.3390/ph10020047

Nguyen, C. T. T., Nguyen, N. H., Choi, W. S., Lee, J. H., & Cheong, J. J. (2022). Biosynthesis of essential oil compounds in Ocimum tenuiflorum is induced by abiotic stresses. Plant Biosystems-An International Journal Dealing with all Aspects of Plant Biology, 156(2), 353-357.

Nisar, M. F., Khadim, M., Rafiq, M., Chen, J., Yang, Y., & Wan, C. C. (2021). Pharmacological properties and health benefits of eugenol: A comprehensive review. Oxidative medicine and cellular longevity, 2021(1), 2497354.

Nörr, H., & Wagner, H. (1992). New constituents from Ocimum sanctum. Planta medica, 58(06), 574-574.

Nouri, A., Heibati, F., & Heidarian, E. (2021). Gallic acid exerts anti-inflammatory, anti-oxidative stress, and nephroprotective effects against paraquat-induced renal injury in male rats. Naunyn-Schmiedeberg's archives of pharmacology, 394, 1-9.

Padalia, R. C., & Verma, R. S. (2011). Comparative volatile oil composition of four Ocimum species from northern India. Natural Product Research, 25(6), 569-575.

Parikh, N. R., Mandal, A., Bhatia, D., Siveen, K. S., Sethi, G., & Bishayee, A. (2014). Oleanane triterpenoids in the prevention and therapy of breast cancer: current evidence and future perspectives. Phytochemistry reviews, 13, 793-810.

Pariza, M. W., Park, Y., & Cook, M. (2000). Mechanisms of action of conjugated linoleic acid: evidence and speculation (44457). Proceedings of the society for experimental biology and medicine, 223(1), 8-13.

Pathak, I., & Niraula, M. (2019). Assessment of total phenolic, flavonoid content and antioxidant activity of Ocimum sanctum Linn. Journal of Nepal chemical society, 40, 30-35.

Pattanayak, P., Behera, P., Das, D., & Panda, S. K. (2010). Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview. Pharmacognosy reviews, 4(7), 95.

Patwardhan, B., Warude, D., Pushpangadan, P., & Bhatt, N. (2005). Ayurveda and traditional Chinese medicine: a comparative overview. Evidence‐Based Complementary and Alternative Medicine, 2(4), 465-473.

Polaris Market Research. (2023). Basil extract market size worth $78.68 million by 2032 | CAGR: 3.1%. https://www.polarismarketresearch.com/press-releases/basil-extract-market

Popescu, L., Cojocari, D., Lung, I., Kacso, I., Ciorîţă, A., Ghendov-Mosanu, A., ... & Sturza, R. (2023). Effect of microencapsulated basil extract on cream cheese quality and stability. Molecules, 28(8), 3305.

Prakash, P. A. G. N., & Gupta, N. (2005). Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: a short review. Indian journal of physiology and pharmacology, 49(2), 125.

Rai, M., Singh, A. V., Paudel, N., Kanase, A., Falletta, E., Kerkar, P., ... & Soos, M. (2023). Herbal concoction unveiled: a computational analysis of phytochemicals' pharmacokinetic and toxicological profiles using novel approach methodologies (NAMs). Current Research in Toxicology, 5, 100118.

Reddy, B. J., Vaishnavi, A., Ravishankar, L. V., & Abhishek, T. S. (2024). Exploring Tulsi’s Medicinal Magic: A Guide to Varieties and Healing Powers.

Saharkhiz, M. J., Kamyab, A. A., Kazerani, N. K., Zomorodian, K., Pakshir, K., & Rahimi, M. J. (2014). Chemical compositions and antimicrobial activities of Ocimum sanctum L. essential oils at different harvest stages. Jundishapur journal of microbiology, 8(1), e13720.

Salakhutdinov, N., Volcho, K. & Yarovaya, O. (2017). Monoterpenes as a renewable source of biologically active compounds. Pure and Applied Chemistry, 89(8), 1105-1117. https://doi.org/10.1515/pac-2017-0109

Seo, Y. H., Kang, S. Y., Shin, J. S., Ryu, S. M., Lee, A. Y., Choi, G., ... & Lee, J. (2019). Chemical constituents from the aerial parts of Agastache rugosa and their inhibitory activities on prostaglandin E2 production in lipopolysaccharide-treated RAW 264.7 macrophages. Journal of natural products, 82(12), 3379-3385.

Shah, G. M., Ahmad, F., Panwar, S., Khadka, M. S., Ali, A., & Bisht, S. (2019). Ocimum sanctum [Tulsi]—an alternative additional livelihood option for the poor and smallholder farmers. Sustainability, 11(1), 227.

Shasany, A. K. (2016). The Holy basil (Ocimum sanctum L.) and its genome. Indian J. Hist. Sci, 51(2), 343-350.

Shen, X., Miao, S., Zhang, Y., Guo, X., Li, W., Mao, X., & Zhang, Q. (2024). Stearic acid metabolism in human health and disease. Clinical Nutrition.

Singh, A. (2024, March 24). Tissue culture of Holy Basil - Plant cell technology. Plant Cell Technology. https://plantcelltechnology.com/blogs/blog/blogtissue-culture-of-holy-basil

Singh, D., & Chaudhuri, P. K. (2018). A review on phytochemical and pharmacological properties of Holy basil (Ocimum sanctum L.). Industrial Crops and Products, 118, 367-382.

Singh, S., & Majumdar, D. K. (2019). Therapeutic potential of Tulsi: A holy herb of ancient India. Pharmacognosy Reviews, 13(26), 49-56. doi: 10.4103/phrev.phrev_9_19

Skaltsa, H., Tzakou, O., & Singh, M. (1999). Note polyphenols of Ocimum sanctum from suriname. Pharmaceutical biology, 37(1), 92-94.

Subramanian, M., Chintalwar, G. J., & Chattopadhyay, S. (2005). Antioxidant and radioprotective properties of an Ocimum sanctum polysaccharide. Redox Report, 10(5), 257-264.

Sun, H., Fang, W. S., Wang, W. Z., & Hu, C. (2006). Structure-activity relationships of oleanane-and ursane-type triterpenoids. Botanical Studies, 47(4), 339-368

Suzuki, A., Shirota, O., Mori, K., Sekita, S., Fuchino, H., Takano, A., & Kuroyanagi, M. (2009). Leishmanicidal active constituents from Nepalese medicinal plant Tulsi (Ocimum sanctum L.). Chemical and Pharmaceutical Bulletin, 57(3), 245-251.

ThePlantList, (2013). Version 1.1. Published on the Internet. http://www.theplantlist.org/ tpl1.1/record/kew-137068.

Uma Devi, P., & Satyamitra, M. (2004). Protection against prenatal irradiation‐induced genomic instability and its consequences in adult mice by Ocimum flavonoids, orientin and vicenin. International journal of radiation biology, 80(9), 653-662.

Wang, X. N., Wang, K. Y., Zhang, X. S., Yang, C., & Li, X. Y. (2018). 4-Hydroxybenzoic acid (4-HBA) enhances the sensitivity of human breast cancer cells to adriamycin as a specific HDAC6 inhibitor by promoting HIPK2/p53 pathway. Biochemical and biophysical research communications, 504(4), 812-819.

Wang, X., Zhang, C., & Bao, N. (2023). Molecular mechanism of palmitic acid and its derivatives in tumor progression. Frontiers in oncology, 13, 1224125.

Wiset, L., Poomsa-ad, N., Jindamol, H., Thongtip, A., Mosaleeyanon, K., Toojinda, T., ... & Chutimanukul, P. (2023). Quality and bioactive compound accumulation in two holy basil cultivars as affected by microwave-assisted hot air drying at an industrial scale. Frontiers in Sustainable Food Systems, 7, 1219540. https://doi.org/10.3389/fsufs.2023.1219540

Xie, J., Xiong, S., Li, Y., Xia, B., Li, M., Zhang, Z., ... & Liao, D. (2024). Phenolic acids from medicinal and edible homologous plants: A potential anti-inflammatory agent for inflammatory diseases. Frontiers in Immunology, 15, 1345002.https://doi.org/10.3389/fimmu.2024.1345002

Yadav, R. P., Chaudhary, S. K., Sah, S. R., & Yadav, J. K. (2024). Exploring the Phytochemical Constituents and Bioactivities of Ocimum sanctum (Tulsi). Research Journal on Multi-disciplinary Issues, 5(1), 39-48.

Yadav, S. P., Pathak, P., Kanaujia, A., Das, A., Saxena, M. J., & Kalra, A. (2024a). Health and Therapeutic Uses of Tulsi (Holy Basil). Octa Journal of Environmental Research, 12(1).

Yang, W., Chen, X., Li, Y., Guo, S., Wang, Z., & Yu, X. (2020). Advances in pharmacological activities of terpenoids. Natural Product Communications, 15(3), 1934578X20903555.https://doi.org/10.1177/1934578X20903555

Yang, Y. H., Li, C. X., Zhang, R. B., Shen, Y., Xu, X. J., & Yu, Q. M. (2024). A review of the pharmacological action and mechanism of natural plant polysaccharides in depression. Frontiers in Pharmacology, 15, 1348019. https://doi.org/10.3389/fphar.2024.1348019

Zahran, E. M., Sayed, A. M., Abdelwahab, M. F., Albohy, A., Abdulrazik, B. S., Ibrahim, A. M., ... & Abdelmohsen, U. R. (2021). Identifying the specific-targeted marine cerebrosides against SARS-CoV-2: An integrated computational approach. RSC advances, 11(57), 36042-36059.

Zhang, L., Xie, Q., & Li, X. (2022). Esculetin: A review of its pharmacology and pharmacokinetics. Phytotherapy research, 36(1), 279-298.

Zhang, Y., Qi, Z., Wang, W., Wang, L., Cao, F., Zhao, L., & Fang, X. (2021). Isovitexin inhibits ginkgolic acids-induced inflammation through downregulating SHP2 activation. Frontiers in pharmacology, 12, 630320.https://doi.org/10.3389/fphar.2021.630320 Zhang et al. (2021)

Zielińska-Błajet, M., Pietrusiak, P., & Feder-Kubis, J. (2021). Selected monocyclic monoterpenes and their derivatives as effective anticancer therapeutic agents. International journal of molecular sciences, 22(9), 4763.

Downloads

Published

27.09.2025

Issue

Section

Review Articles