Phytochemical Screening, Antioxidant, Antiulcer, Anti-Inflammatory and Analgesic Activity of the Aqueous Extract of Angelica archangelica
DOI:
https://doi.org/10.24925/turjaf.v10i2.334-340.5023Anahtar Kelimeler:
Angelica archangelica- Phytchemical- Antioxidant activity- Anti-flammatory- Analgesic effect- Anti-ulcer activityÖzet
The objective of this study is to evaluate the antioxidant, antiulcer, anti-inflammatory and analgesic activity of the aqueous extract of Angelica archangelica L., a medicinal plant of the traditional pharmacopoeia of Algeria. The aqueous extract showed a large amount of total polyphenols, tannins, chlorophyll a, b, carotenoids and a small amount of flavonoids with values of 80.16±14.3 mg EAG/g of extract, 3.12±2.01 mg EQ/g of extract, 226.10±4.50 mg EAT/g of extract, 6.10±50.62, 12.00±31.53 and 1.78±0.40 μg/mL respectively. In addition, the aqueous extract of A. archangelica showed a high ability to trap DPPH radical in with IC50 at 16.9±2.03μg/mL. However, the aqueous extract has a great protective effect against β-carotene degradation at 91.98±0.64% after 24 hours and significant ferrous ion chelation activity at46.2 ±1.53µg/mL. Furthermore, the anti-inflammatory activity was studied according to the protein denaturation inhibition method and, according to the results obtained, the extract of A. archangelica at concentrations of 250, 500 μg/mL and 1 mg/mL have ahigh antiinflammatory activity whose inhibition percentages are 78.85±5.31%, 86.65±2.70% and 89.89±0.58% respectively. The analgesic effect of the aqueous extract of A. archangelica, showed that the concentration 400 mg/mL has a greet abdominal cramps inhibitory effect in comparison with the concentration 200 mg/mL with a percentage of 98.28%. The antiulcer effect of the aqueous extract of A. archangelica was evaluated by the 70% ethanol-induced ulcer test. The results obtained reveal that the aqueous extract 200 and 400 mg/mL exerted a considerable effect of protecting the stomach at 86.55±3.51% and 82.82±2.18% respectively.İndir
Yayınlanmış
Nasıl Atıf Yapılır
Sayı
Bölüm
Lisans
Bu çalışma Creative Commons Attribution-NonCommercial 4.0 International License ile lisanslanmıştır.