Süt Kaynaklı Biyoaktif Bileşenlerin Antidiyabetik Etkisi
DOI:
https://doi.org/10.24925/turjaf.v13i3.814-820.7306Anahtar Kelimeler:
Süt- Biyoaktif Bileşenler- Tip 2 Diyabet MellitusÖzet
Tip 2 diyabet (T2DM), vücudun insülin hormonunu etkili bir şekilde kullanamamasıyla karakterize edilen ve yüksek kan şekeri seviyelerine yol açan kronik bir metabolik hastalıktır. Süt, T2DM yönetiminde olumlu etkileri olduğu belirtilen önemli besin bileşenleri bakımından zengin bir kaynaktır. Sütte kaynaklı biyoaktif bileşenler, süt proteinlerinden, yağlarından ve diğer bileşenlerinden türeyen, vücutta çeşitli biyolojik aktiviteler gösteren ve sağlık üzerinde olumlu etkiler sağlayan moleküllerdir. Bu bileşenler (proteinler, peptitler, yağ asitleri), süt ürünlerinin tüketimi sırasında ya da süt proteinlerinin sindirilmesi ve hidroliz edilmesi sonucunda ortaya çıkmaktadır. Son dönemde yapılan müdahale çalışmaları, süt kaynaklı biyoaktif proteinlerin, peptitlerin ve yağ asitlerinin T2DM'nin önlenmesi ve yönetiminde yararlı etkiler sağladığını göstermektedir. Süt biyoaktif bileşenleri arasında kazein, kazein türevi peptitler, peynir altı suyu proteinleri ve peynir altı suyu proteini türevi peptitler yer almaktadır. Bu biyoaktif bileşenler, çeşitli mekanizmalar aracılığıyla anti-diyabetik etkiler göstermektedir. Bu mekanizmalar arasında insülin duyarlılığının artırılması, glukoz metabolizmasının düzenlenmesi ve inflamasyonun azaltılması yer almaktadır. İnsanlarda gerçekleştirilen müdahale çalışmaları sonucunda, süt kaynaklı bu biyoaktif bileşenlerin açlık kan şekeri seviyelerini düşürdüğünü ve insülin duyarlılığını artırdığı ortaya koyulmuştur. Bu çalışma, sütten elde edilen biyoaktif bileşiklerin (proteinler, peptitler ve yağ asitleri) anti-diyabetik etkilerini ve bu bileşiklerin T2DM yönetimindeki etki mekanizmalarını inceleyen güncel çalışmaları kapsamlı bir şekilde ele almaktadır. Böylece, süt biyoaktif bileşenlerinin T2DM üzerindeki potansiyel faydaları ve klinik uygulamaları hakkında bir bakış açısı sunmaktadır.
Referanslar
Akhavan T, Luhovyy BL, Brown PH, Cho CE, Anderson GH. (2010). Effect of premeal consumption of whey protein and its hydrolysate on food intake and postmeal glycemia and insulin responses in young adults. Am J Clin Nutr 91:966–975.
Akhavan T, Luhovyy BL, Panahi S, Kubant R, Brown PH, Anderson GH. (2014). Mechanism of action of pre-meal consumption of whey protein on glycemic control in young adults. The Journal of nutritional biochemistry, 25(1), 36-43.
Alvarez-Bueno C, Cavero-Redondo I, Martinez-Vizcaino V, Sotos-Prieto M, Ruiz JR, Gil A. (2019). Effects of milk and dairy product consumption on type 2 diabetes: overview of systematic reviews and meta-analyses. Advances in Nutrition, 10, 154-163.
Amigo-Benavent M, Power-Grant O, FitzGerald, RJ, Jakeman P. (2020). The insulinotropic and incretin response to feeding a milkbased protein matrix in healthy young women. Journal of Functional Foods, 72, 104056.
Bailey CJ, Flatt PR, (1995). Development of antidiabetic drugs. In: Ioannides C, Flatt PR. (Eds.), Drugs, Diet and Disease: Mechanistic Approaches toDiabetes. Ellis Horwood, London, pp. 279–326.
Bjørnshave A, Holst JJ, Hermansen K. (2018). Pre-meal effect of whey proteins on metabolic parameters in subjects with and without type 2 diabetes: a randomized, crossover trial. Nutrients, 10(2), 122.
Chalamaiah M, Yu W, Wu J. (2018). Immunomodulatory and anticancer protein hydrolysates (peptides) from food proteins: A review. Food chemistry, 245, 205-222.
Derosa G, D'angelo, A, Maffioli P. (2020). Change of some oxidative stress parameters after supplementation with whey protein isolate in patients with type 2 diabetes. Nutrition, 73, 110700.
Ejtahed HS, Naslaji AN, Mirmiran P, Yeganeh MZ, Hedayati M, Azizi F, Movahedi AM. (2015). Effect of camel milk on blood sugar and lipid profile of patients with type 2 diabetes: a pilot clinical trial. International journal of endocrinology and metabolism, 13(1).
Geerts BF, Dongen MGV, Flameling B, Moerland MM, Kam MLD, Cohen AF, Rominjn JA, Gerhardt CC, Kloek J, Burggraaf J. (2011). Hydrolyzed casein decreases postprandial glucose concentrations in T2DM patients irrespective of leucine content. Journal of dietary supplements, 8(3), 280-292.
Gerich JE. (2003) Clinical significance, pathogenesis, and management of postprandial hyperglycemia. Arch Intern Med 16:1306–1316.
Gong H, Gao J, Wang Y, Luo QW, Guo KR, Ren FZ, Mao XY. (2020). Identification of novel peptides from goat milk casein that ameliorate high-glucose-induced insulin resistance in HepG2 cells. Journal of Dairy Science, 103(6), 4907-4918.
Goudarzi M, Madadlou A. (2013). Influence of whey protein and its hydrolysate on prehypertension and postprandial hyperglycaemia in adult men. International Dairy Journal, 33(1), 62-66.
Gregersen S, Bystrup S, Overgaard A, Jeppesen PB, Thorup ACS, Jensen E, Hermansen K. (2014). Effects of whey proteins on glucose metabolism in normal Wistar rats and Zucker diabetic fatty (ZDF) rats. The review of diabetic studies: RDS, 10(4), 252.
Hirahatake KM, Astrup A, Hill JO, Slavin JL, Allison DB, Maki KC. (2020) Potential Cardiometabolic Health Benefits of Full-Fat Dairy: The Evidence Base. Adv. Nutr. 11, 533–547.
Hu FB, Manson JE, Willett WC. (2001) Types of dietary fat and risk of coronary heart disease: A critical review. J. Am. Coll. Nutr. 20, 5–19.
International Diabetes Federation. Diabetes Atlas. 10th edition, IDF Publ., Brussels: 2021. https://diabetesatlas.org/ tenth-edition/. Erişim tarihi: 07 Ocak 2025.
Jayathilakan K, Ahirwar R, Pandey MC. (2018). Bioactive compounds and milk peptides for human health-a review. Novel Techniques in Nutrition & Food Science, 1(5), 116-122.
Jakubowicz D, Wainstein J, Landau Z, Ahren B, Barnea M, Bar-Dayan Y, Froy O. (2017). High-energy breakfast based on whey protein reduces body weight, postprandial glycemia and HbA1C in Type 2 diabetes. The Journal of nutritional biochemistry, 49, 1-7.
Jensen C, Dale HF, Hausken T, Lied E, Hatlebakk JG, Brønstad I, Lied GA, Hoff DAL. (2019). Supplementation with cod protein hydrolysate in older adults: A dose range cross-over study. Journal of nutritional science, 8, e40.
Jonker JT, Wijngaarden MA, Kloek J, Groeneveld Y, Gerhardt C, Brand R, Kres AK, Smit JWA. (2011). Effects of low doses of casein hydrolysate on post-challenge glucose and insulin levels. European journal of internal medicine, 22(3), 245-248.
King DG, Walker M, Campbell MD, Breen L, Stevenson EJ, West DJ. (2018). A small dose of whey protein co-ingested with mixed-macronutrient breakfast and lunch meals improves postprandial glycemia and suppresses appetite in men with type 2 diabetes: a randomized controlled trial. The American journal of clinical nutrition, 107(4), 550-557.
Lacroix IM, Li-Chan EC. (2012). Dipeptidyl peptidase-IV inhibitory activity of dairy protein hydrolysates. International Dairy Journal, 25(2), 97-102.
Lacroix IM, Li-Chan EC. (2013). Inhibition of dipeptidyl peptidase (DPP)-IV and α-glucosidase activities by pepsin-treated whey proteins. Journal of agricultural and food chemistry, 61(31), 7500-7506.
Lacroix IM, Li-Chan EC. (2014). Isolation and characterization of peptides with dipeptidyl peptidase-IV inhibitory activity from pepsin-treated bovine whey proteins. Peptides, 54, 39-48.
Lacroix IM, Li-Chan EC. (2016). Food-derived dipeptidyl-peptidase IV inhibitors as a potential approach for glycemic regulation–Current knowledge and future research considerations. Trends in Food Science & Technology, 54, 1-16.
Le Maux S, Nongonierma AB, FitzGerald RJ. (2017). Peptide composition and dipeptidyl peptidase IV inhibitory properties of β-lactoglobulin hydrolysates having similar extents of hydrolysis while generated using different enzyme-to-substrate ratios. Food Research International, 99, 84-90.
Manders RJ, Hansen D, Zorenc AH, Dendale P, Kloek J, Saris WH, van Loon LJ. (2014). Protein co-ingestion strongly increases postprandial insulin secretion in type 2 diabetes patients. Journal of medicinal food, 17(7), 758-763.
Mitri J, Yusof B-NM, Maryniuk M, Schrager C, Hamdy O, Salsberg V. (2019) Dairy intake and type 2 diabetes risk factors: A narrative review. Diabetes Metab. Syndr. Clin. Res. Rev. 13, 2879–2887.
Morato PN, Lollo PCB, Moura CS, Batista TM, Camargo RL, Carneiro EM, Amaya-Farfan J. (2013). Whey protein hydrolysate increases translocation of GLUT-4 to the plasma membrane independent of insulin in wistar rats. PloS one, 8(8), e71134.
Nilsson M, Holst JJ, Bjorck IM, (2007). Metabolic effects of amino acid mixtures and whey protein in healthy subjects: studies using glucose-equivalent drinks. Am. J. Clin. Nutr., 85: 996–1004.
Power O, Hallihan A, Jakeman P, (2009). Human insulinotropic response to oral ingestion of native and hydrolysed whey protein. Amino Acids, 37, 333e339.
Nongonierma AB, FitzGerald RJ. (2013). Dipeptidyl peptidase IV inhibitory and antioxidative properties of milk protein-derived dipeptides and hydrolysates. Peptides, 39, 157-163.
Nongonierma AB, Cadamuro C, Le Gouic A, Mudgil P, Maqsood S, FitzGerald RJ. (2019). Dipeptidyl peptidase IV (DPP-IV) inhibitory properties of a camel whey protein enriched hydrolysate preparation. Food Chemistry, 279, 70-79.
Pal S, Ellis V, Dhaliwal S. (2010). Effects of whey protein isolate on body composition, lipids, insulin and glucose in overweight and obese individuals. British journal of nutrition, 104(5), 716-723.
Patil P, Mandal S, Tomar SK, Anand S. (2015). Food protein-derived bioactive peptides in management of type 2 diabetes. European journal of nutrition, 54, 863-880.
Ryder JW, Portocarrero CP, Song XM, Cui L, Yu M, Combatsiaris T, Galuska D, Bauman DE, Barbano DM, Charron MJ, Zierath JR, Houseknecht KL. (2001). Isomer-specific antidiabetic properties of conjugated linoleic acid: improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression. Diabetes, 50(5), 1149-1157.
Saleh L, Schrier NL, Bruins MJ, Steegers EA, van den Meiracker AH, Visser W. (2018). Effect of oral protein hydrolysate on glucose control in patients with gestational diabetes. Clinical Nutrition, 37(3), 878-883.
Sartorius T, Weidner A, Dharsono T, Boulier A, Wilhelm M, Schön C. (2019). Postprandial effects of a proprietary milk protein hydrolysate containing bioactive peptides in prediabetic subjects. Nutrients, 11(7), 1700.
Silveira ST, Martínez-Maqueda D, Recio I, Hernández-Ledesma B. (2013). Dipeptidyl peptidase-IV inhibitory peptides generated by tryptic hydrolysis of a whey protein concentrate rich in β-lactoglobulin. Food chemistry, 141(2), 1072-1077.
Tulipano G, Sibilia V, Caroli AM, Cocchi D. (2011). Whey proteins as source of dipeptidyl dipeptidase IV (dipeptidyl peptidase- 4) inhibitors. Peptides, 32 (4), 835–838.
Vlaeminck B, Fievez V, Cabrita ARJ, Fonseca AJM, Dewhurst RJ. (2006) Factors affecting odd-and branched-chain fatty acids in milk: A review. Anim. Feed Sci. Technol. 131, 389–417.
WHO, (2006). Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: report of a WHO/IDF consultation.
WHO, (2011). Global status report on noncommunicable diseases 2010. World Health Organization, WHO Press.
Wongtangtintharn S, Oku H, Iwasaki H, Toda T. (2004). Effect of branched-chain fatty acids on fatty acid biosynthesis of human breast cancer cells. J. Nutr. Sci. Vitaminol. 50, 137–143.
Yang X, Li Y, Wang C, Mao Z, Zhou W, Zhang L, Fan M, Cui S, Li, L. (2020). Meat and fish intake and type 2 diabetes: Dose–response meta-analysis of prospective cohort studies. Diabetes & metabolism, 46(5), 345-352.
Yuan QC, Zhan BY, Du M, Chang R, Li TG, Mao XY. (2019). Dietary milk fat globule membrane regulates JNK and PI3K/Akt pathway and ameliorates type 2 diabetes in mice induced by a high-fat diet and streptozotocin. Journal of Functional Foods, 60, 103435.
Zhou X, Chai L, Wu Q, Wang Y, Li S, Chen J. (2021). Anti-diabetic properties of bioactive components from fish and milk. Journal of Functional Foods, 85, 104669.
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