Süt Kaynaklı Biyoaktif Bileşenlerin Antidiyabetik Etkisi
DOI:
https://doi.org/10.24925/turjaf.v13i3.814-820.7306Anahtar Kelimeler:
Süt- Biyoaktif Bileşenler- Tip 2 Diyabet MellitusÖzet
Tip 2 diyabet (T2DM), vücudun insülin hormonunu etkili bir şekilde kullanamamasıyla karakterize edilen ve yüksek kan şekeri seviyelerine yol açan kronik bir metabolik hastalıktır. Süt, T2DM yönetiminde olumlu etkileri olduğu belirtilen önemli besin bileşenleri bakımından zengin bir kaynaktır. Sütte kaynaklı biyoaktif bileşenler, süt proteinlerinden, yağlarından ve diğer bileşenlerinden türeyen, vücutta çeşitli biyolojik aktiviteler gösteren ve sağlık üzerinde olumlu etkiler sağlayan moleküllerdir. Bu bileşenler (proteinler, peptitler, yağ asitleri), süt ürünlerinin tüketimi sırasında ya da süt proteinlerinin sindirilmesi ve hidroliz edilmesi sonucunda ortaya çıkmaktadır. Son dönemde yapılan müdahale çalışmaları, süt kaynaklı biyoaktif proteinlerin, peptitlerin ve yağ asitlerinin T2DM'nin önlenmesi ve yönetiminde yararlı etkiler sağladığını göstermektedir. Süt biyoaktif bileşenleri arasında kazein, kazein türevi peptitler, peynir altı suyu proteinleri ve peynir altı suyu proteini türevi peptitler yer almaktadır. Bu biyoaktif bileşenler, çeşitli mekanizmalar aracılığıyla anti-diyabetik etkiler göstermektedir. Bu mekanizmalar arasında insülin duyarlılığının artırılması, glukoz metabolizmasının düzenlenmesi ve inflamasyonun azaltılması yer almaktadır. İnsanlarda gerçekleştirilen müdahale çalışmaları sonucunda, süt kaynaklı bu biyoaktif bileşenlerin açlık kan şekeri seviyelerini düşürdüğünü ve insülin duyarlılığını artırdığı ortaya koyulmuştur. Bu çalışma, sütten elde edilen biyoaktif bileşiklerin (proteinler, peptitler ve yağ asitleri) anti-diyabetik etkilerini ve bu bileşiklerin T2DM yönetimindeki etki mekanizmalarını inceleyen güncel çalışmaları kapsamlı bir şekilde ele almaktadır. Böylece, süt biyoaktif bileşenlerinin T2DM üzerindeki potansiyel faydaları ve klinik uygulamaları hakkında bir bakış açısı sunmaktadır.
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