Gluten ve Gluten Metabolizması Bozukluğuna Bağlı Oluşan Hastalıklar
DOI:
https://doi.org/10.24925/turjaf.v12i7.1225-1230.6694Anahtar Kelimeler:
glüten- gliadin- çölyak- Buğday alerjisi - Çölyak dışı gluten duyarlılığıÖzet
İnsanların beslenmesinde gluten içeren besinler önemli yer tutmaktadır. Gluten metabolizması bozukluğuna bağlı oluşan hastalıklar bulunmakta olup bunlar çölyak hastalığı, buğdaya karşı IgE aracılı alerji ve çölyak dışı gluten duyarlılığı olarak sınıflandırılabilir. Bireylerin gluten duyarlılıkları arasında farklılıklar olup gluten duyarlılığı olan bireylerin gluten içeren besinleri tüketmeleri durumunda en başta bağırsak dokusu olmak üzere birçok dokuda histopatolojik yapılarında ve otoimmun sistemlerinde önemli değişiklikler meydana gelebilir. Dokuların histopatolojik yapısındaki değişiklikler dokulara göre değişmektedir. Otoimmun sistemdeki değişiklikler ise Transglutaminaz, Gliadin, IgA, IgG, CD4 ve CD8 gibi parametrelerden en az birinin veya birkaçının incelenmesi ile tespit edilebilir. Gluten metabolizması bozukluğuna bağlı oluşan hastalıklarda etkili tedavi şekli glutensiz/gluten kısıtlı diyet olmakla birlikte bağışıklık sisteminde rol alan mekanizma ve moleküllerin saptanması yeni tedavi yöntemlerini oluşturulmasına yol gösterebilir. Bu çalışmada amaç gluten ve gluten metabolizması bozukluğuna bağlı oluşan hastalıklar arasındaki ilişkinin derlemesidir.
Referanslar
Abdi, F., Zuberi, S., Blom, J. J., Armstrong, D., & Pinto-Sanchez, M. I. (2023). Nutritional considerations in celiac disease and non-celiac gluten/wheat sensitivity. Nutrients, 15(6), 1475.
Akobeng, A. K., & Thomas, A. G. (2008). Systematic review: tolerable amount of gluten for people with coeliac disease. Alimentary pharmacology & therapeutics, 27(11), 1044-1052.
Aziz, I., Branchi, F., & Sanders, D. S. (2015). The rise and fall of gluten!. Proceedings of the nutrition society, 74(3), 221-226.
Baniwal, P., Mehra, R., Kumar, N., Sharma, S., & Kumar, S. (2021). Cereals: Functional constituents and its health benefits. The Pharma Innovation, 10(2), 343-349.
Biesiekierski, J. R. (2017). What is gluten?. Journal of gastroenterology and hepatology, 32, 78-81.
Cabanillas, B. (2020). Gluten-related disorders: Celiac disease, wheat allergy, and nonceliac gluten sensitivity. Critical reviews in food science and nutrition, 60(15), 2606-2621.
Calado, J., & Verdelho Machado, M. (2022). Celiac disease revisited. GE-Portuguese Journal of Gastroenterology, 29(2), 111-124.
Cárdenas-Torres, F. I., Cabrera-Chávez, F., Figueroa-Salcido, O. G., & Ontiveros, N. (2021). Non-celiac gluten sensitivity: An update. Medicina, 57(6), 526.
Cenni, S., Sesenna, V., Boiardi, G., Casertano, M., Russo, G., Reginelli, A., ... & Strisciuglio, C. (2023). The Role of Gluten in Gastrointestinal Disorders: A Review. Nutrients, 15(7), 1615.
Demirçeken, F. G. (2011). Gluten enteropatisi (çölyak hastalığı): Klasik bir öykü ve güncel gelişmeler. Güncel Gastroenteroloji, 15(1), 58-72.
Demirçeken, F. G., Kansu, A., Kuloğlu, Z., Girgin, N., Güriz, H., & Ensari, A. (2008). Human tissue transglutaminase antibody screening by immunochromatographic line immunoassay for early diagnosis of celiac disease in Turkish children.
Emiroğlu M. (2017), "Türkiye’nin Beslenme Problemi Ve Buğday Üretimi", Ankara Üniversitesi Dil Ve Tarih-Coğrafya Fakültesi Dergisi, 22 (1-2).
Ertem D. (2014) "Çölyak Hastalığı", Klinik Tıp Pediatri Dergisi, 9 (1), 1-10.
Güleç, S. G., Urgancı, N., Gül, F., Emecen, M., & Erdem, E. (2011). Çocuklarda çölyak hastalığının tanı ve takibinde doku transglutaminaz-IgA antikorunun yeri. Ş. EEAH Tıp Bülteni, 45, 119-23.
Green PH, Cellier C.(2007), Celiac disease. N Engl J Med ;357:1731-43.
Gümüş, R., Uslu, S., Aydoğdu, U., İmik, A., & Ekici, M. (2021). Investigation of the effects of glutens on serum interleukin-1 beta and tumor necrosis factor-alpha levels and the immunohistochemical distribution of CD3 and CD8 receptors in the small intestine in male rats. Brazilian Archives of Biology and Technology, 64.
Gümüş R, Terim Kapakin KA, Manavoğlu Kirman E, Bolat İ, İmik A, Ercan N(2024) The effect of adding wheat and corn gluten to the diet of rats on the autoimmune and histopathological parameters in the intestine and liver. University Of Zulia Faculty Of Veterınary Sciences Revista Cientifica (Vol: 34 (1) of 2024 (In press).
Hudacko R., Zhou X. K., Yantiss R. K. (2013), "Immunohistochemical Stains For Cd3 And Cd8 Do Not Improve Detection Of Gluten-Sensitive Enteropathy In Duodenal Biopsies", Modern Pathology, 26 (9), 1241.
Husby, S., Koletzko, S., Korponay-Szabó, I. R., Mearin, M. L., Phillips, A., Shamir, R., ... & ESPGHAN Gastroenterology Committee. (2012). European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. Journal of pediatric gastroenterology and nutrition, 54(1), 136-160.
Ierardi, E., Losurdo, G., Piscitelli, D., Giorgio, F., Amoruso, A., Iannone, A., ... & Di Leo, A. (2018). Biological markers for non-celiac gluten sensitivity: a question awaiting for a convincing answer. Gastroenterology and Hepatology From bed to Bench, 11(3), 203.
Iversen, R., & Sollid, L. M. (2023). The immunobiology and pathogenesis of celiac disease. Annual Review of Pathology: Mechanisms of Disease, 18, 47-70.
İmik A, Gezer C, Terim Kapakin KA (2024) Investigation of the Effect of Wheat and Corn Gluten on Inflammation, Transglutaminase, Gliadin and Ig A Levels in Healthy Rat Intestines. Veterinary Sciences and Practices. (AUJVS-2023-49 – 190) In Press
Karaahmet F. (2018), "Çölyak Hastalığı'nda Teşhis Süresi", Ege Tıp Dergisi, 57 (4), 228-231.
Korponay-Szabó, I. R., Dahlbom, I., Laurila, K., Koskinen, S., Woolley, N., Partanen, J., ... & Hansson, T. (2003). Elevation of IgG antibodies against tissue transglutaminase as a diagnostic tool for coeliac disease in selective IgA deficiency. Gut, 52(11), 1567.
Korponay–Szabo´ IR, Sulkanen S, Halttunen T, Maurano F, Rossi M, Mazzarella G, Laurila K, Troncone R, and Ma¨ki M (2000)Tissue Transglutaminase Is the Target in Both Rodent and Primate Tissues for Celiac Disease–Specific Autoantibodies. Journal of Pediatric Gastroenterology and Nutrition, 31:520–527.
Lebwohl, B., & Rubio-Tapia, A. (2021). Epidemiology, presentation, and diagnosis of celiac disease. Gastroenterology, 160(1), 63-75.
Liu, W., Wu, Y., Wang, J., Wang, Z., Gao, J., Yuan, J., & Chen, H. (2023). A Meta-Analysis of the Prevalence of Wheat Allergy Worldwide. Nutrients, 15(7), 1564.
Lobo, G. C., & Aguiar, I. V. (2023). Genetic markers of non-celiac gluten sensitivity. Caderno de ANAIS HOME
Lohiniemi, S., Mäki, M., Kaukinen, K., Laippala, P., & Collin, P. (2000). Gastrointestinal symptoms rating scale in coeliac disease patients on wheat starch-based gluten-free diets. Scandinavian journal of gastroenterology, 35(9), 947-949.
Losurdo, G., Principi, M., Iannone, A., Amoruso, A., Ierardi, E., Di Leo, A., & Barone, M. (2018). Extra-intestinal manifestations of non-celiac gluten sensitivity: An expanding paradigm. World journal of gastroenterology, 24(14), 1521.
Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PH, Hadjivassiliou M, Kaukinen K, Kelly CP, Leonard JN, Lundin KE, Murray JA, Sanders DS, Walker MM, Zingone F, Ciacci C.(2013) The Oslo definitions for coeliac disease and related terms. Gut. 62:43–52.
Maiuri, L., Ciacci, C., Ricciardelli, I., Vacca, L., Raia, V., Auricchio, S., ... & Londei, M. (2003). Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. The Lancet, 362(9377), 30-37.
Mandile, R., Maglio, M., Mosca, C., Marano, A., Discepolo, V., Troncone, R., & Auricchio, R. (2022). Mucosal healing in celiac disease: Villous architecture and immunohistochemical features in children on a long-term gluten free diet. Nutrients, 14(18), 3696.
Marietta, E. V., & Murray, J. A. (2012, July). Animal models to study gluten sensitivity. In Seminars in immunopathology (Vol. 34, No. 4, pp. 497-511). Berlin/Heidelberg: Springer-Verlag.
Marietta, E. V., David, C. S., & Murray, J. A. (2011). Important lessons derived from animal models of celiac disease. International reviews of immunology, 30(4), 197-206.
Mędza, A., & Szlagatys-Sidorkiewicz, A. (2023). Nutritional Status and Metabolism in Celiac Disease: Narrative Review. Journal of Clinical Medicine, 12(15), 5107.
Melini, V., & Melini, F. (2019). Gluten-free diet: Gaps and needs for a healthier diet. Nutrients, 11(1), 170.
Morita, E., Matsuo, H., Kohno, K., Yokooji, T., Yano, H., & Endo, T. (2023). A Narrative Mini Review on Current Status of Hypoallergenic Wheat Development for IgE-Mediated Wheat Allergy, Wheat-Dependent Exercise-Induced Anaphylaxis. Foods, 12(5), 954.
Nordqvist, P., Thedjil, D., Khosravi, S., Lawther, M., Malmström, E., & Khabbaz, F. (2012). Wheat gluten fractions as wood adhesives—glutenins versus gliadins. Journal of Applied Polymer Science, 123(3), 1530-1538.
Pekki, H., Kurppa, K., Mäki, M., Huhtala, H., Sievänen, H., Laurila, K., ... & Kaukinen, K. (2015). Predictors and significance of incomplete mucosal recovery in celiac disease after 1 year on a gluten-free diet. Official journal of the American College of Gastroenterology| ACG, 110(7), 1078-1085.
Roshanzamir, N., Zakeri, Z., Rostami-Nejad, M., Sadeghi, A., Pourhoseingholi, M. A., Shahbakhsh, Y., ... & Rezaei-Tavirani, M. (2021). Prevalence of celiac disease in patients with atypical presentations. Arab Journal of Gastroenterology, 22(3), 220-223.
Sahin, Y. (2021). Celiac disease in children: A review of the literature. World journal of clinical pediatrics, 10(4), 53.
Schalk, K., Lexhaller, B., Koehler, P., & Scherf, K. A. (2017). Isolation and characterization of gluten protein types from wheat, rye, barley and oats for use as reference materials. PloS one, 12(2), e0172819.
Singh, P., Arora, A., Strand, T. A., Leffler, D. A., Catassi, C., Green, P. H., ... & Makharia, G. K. (2018). Global prevalence of celiac disease: systematic review and meta-analysis. Clinical gastroenterology and hepatology, 16(6), 823-836.
Šmídová, Z., & Rysová, J. (2022). Gluten-free bread and bakery products technology. Foods, 11(3), 480.
Soya, S., & Ün, C. (2014). Çölyak hastalığındaki moleküler ve genetik gelişmeler. Çocuk Sağlığı ve Hastalıkları Dergisi, 57, 274-282.
Sümer, S. A. G., Harmandar, F. A., Uyar, S., & Çekin, A. H. (2015). Non-Çölyak gluten duyarlılığı. Güncel Gastroenteroloji, 19(2), 91-97.
Tunç, N., Şahin, A., Orhan, S., Yalnız, M., Demirel, U., Poyrazoğlu, O.K., & Bahçecioğlu, İ.H. (2016). Çölyak hastalığı; 5 yıllık takip, antikor-patoloji korelasyonu. Endoskopi Gastrointestinal, 24(2), 43-46.
Türksoy S., Özkaya B., (2006), "Gluten ve Çölyak hastalığı", Türkiye 9, 24-26.
Türkiye Beslenme Rehberi TÜBER(2022). T. C. Sağlık Bakanlığı Yayın No:1031, ISBN: 978-975-590-867-0, ANKARA 2022.
Valvano, M., Longo, S., Stefanelli, G., Frieri, G., Viscido, A., & Latella, G. (2020). Celiac disease, gluten-free diet, and metabolic and liver disorders. Nutrients, 12(4), 940.
Wieser, H., Koehler, P., & Scherf, K. A. (2020). The two faces of wheat. Frontiers in nutrition, 7, 517313.
Wieser, H., Koehler, P., & Scherf, K. A. (2023). Chemistry of wheat gluten proteins: Qualitative composition. Cereal Chemistry, 100(1), 23-35.
Xu, Y., Sun, X. S., & Wang, D. (2019). Wheat. In Integrated Processing Technologies for Food and Agricultural By-Products (pp. 3-20). Academic Press.
Yanar, Ö., Durmaz, Ö., & Gökçay, G. (2013). Atipik Başlangıçlı Çölyak Hastalığı. Journal of the Child/Cocuk Dergisi, 13(3).
Yönal, O., & Özdil, S. (2014). Çölyak hastalığı. Güncel Gastroentoloji, 18(1), 93-100.
Yu, W., Freeland, D. M. H., & Nadeau, K. C. (2016). Food allergy: immune mechanisms, diagnosis and immunotherapy. Nature Reviews Immunology, 16(12), 751-765.
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